Publications - Cipitria Lab
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Publications

2024

Young, S. A. E., Heller, A.-D., Garske, D. S., Rummler, M., Qian, V., Ellinghaus, A., Duda, G. N., Willie, B. M., Grüneboom, A., Cipitria, A.: From breast cancer cell homing to the onset of early bone metastasis: The role of bone (re)modeling in early lesion formation. Science Advances 10, eadj0975 (2024)

Tam, N., Schullian, O., Cipitria, A., Dimova, R.: Nonspecific membrane-matrix interactions influence diffusivity of lipid vesicles in hydrogels. Biophysical Journal 123, 1-13 (2024)

Garrido, C. A., Garske, D. S., Amini, S., Duda, G. N., Schmidt-Bleek, K., Cipitria, A.: 3D patterns in alginate hydrogel degradation spatially guide YAP nuclear translocation and hMSC osteogenic differentiation. bioRxiv, 2024.04.11.588803 (2024)

Heller, A.-D., Young, S. A. E., Valleriani, A., Cipitria, A.: A Stochastic Cellular Automaton Model to simulate Bone Remodeling. bioRxiv, 2023.12.21.572505 (2024)

Garcia-Carrizo. F., Gohlke, S., Lenihan-Geels, G., Jank, A.-M., Leer, M., Soultoukis, G.A., Oveisi, M., Herpich, C., Garrido, C.A., Kotsaris, G., Pöhle-Kronawitter, S., Tsamo-Tetou, A., Graja, A., Ost, M., Villacorta, L., Knecht, R.S., Klaus, S., Schürmann, A., Stricker, S., Schmidt-Bleek, K., Cipitria, A., Duda, G.N., Benes, V., Müller-Werdan, U., Norman, K, Schulz, T.J.: Aging impairs skeletal muscle regeneration by promoting fibro/fatty degeneration and inhibiting inflammation resolution via fibro-adipogenic progenitors. bioRxiv 2023.11.27.568776 (2024)

2023

Moreno-Jiménez, I., Heinig, S., Heras, U., Maichl, D.S., Strifler, S., Leich-Zbat, E., Blouin, S., Fratzl, P., Fratzl-Zelman, N., Jundt, F., Cipitria, A. 3D osteocyte lacunar morphometry of human bone biopsies with high resolution microCT: from monoclonal gammopathy to newly diagnosed multiple myeloma. bioRxiv, 2023.07.12.548656 (2023)

Bakhshandeh, S., Taïeb, H. M., Varadarajan, A. R., Lissek, S. M., Hücker, S. M., Lu, X., Garske, D. S., Young, S. A. E., Contzen, J., Gossen, M., Kirsch, S., Warfsmann, J., Honarnejad, K., Klein, C. A., Cipitria, A. Quiescence-inducing 3D-engineered matrix uncovers mechanosensitive and drug protective FHL2-p21 signaling axis. bioRxiv 2023.01.25.525382 (2023)

Young, S. A. E., Heller, A.-D., Garske, D. S., Rummler, M., Qian, V., Ellinghaus, A., Duda, G. N., Willie, B. M., Grüneboom, A., Cipitria, A. From breast cancer cell homing to the onset of early bone metastasis: dynamic bone (re)modeling as a driver of osteolytic disease. bioRxiv 2023.01.24.525352 (2023)

Tam, N., Schullian, O., Cipitria, A., Dimova, R. Non-specific membrane-matrix interactions influence diffusivity of lipid vesicles in hydrogel environments. bioRxiv, 2023.02. 03.526937 (2023)

Sparks, D.S., Savi, F.M., Dlaska, C.E., Saifzadeh, S., Brierly, G., Ren, E., Cipitria, A., Reichert, J.C., Wille, M.L., Schuetz, M.A., Ward, N., Wagels, M., Hutmacher, D.W.: Convergence of scaffold-guided bone regeneration principles and microvascular tissue transfer surgery. Science Advances 9, eadd6071 (2023).

Garrido, C. A., Garske, D. S., Thiele, M., Amini, S., Real, S., Duda, G. N., Schmidt-Bleek, K., Cipitria, A.: Hydrogels with stiffness-degradation spatial patterns control anisotropic 3D cell response. Biomaterials Advances 151, 213423 (2023)

Taïeb, H. M., Herment, G., Robinson, T., Cipitria, A.: Effect of capillary fluid flow on single cancer cell cycle dynamics, motility, volume and morphology. Lab on a Chip 23, 92-105 (2023).

Schamberger, B., Roschger, A., Ziege, R., Anselme, K., Amar, M.B., Bykowski, M., Castro, A.P.G., Cipitria, A., Coles, R., Dimova, R., Eder, M., Ehrig, S., Escudero, L.M., Evans, M.E., Fernandes, P.R., Fratzl, P., Geris, L., Gierlinger, N., Hannezo, E., Iglič, A., Kirkensgaard, J.J.K., Kollmannsberger, P., Kowalewska, Ł., Kurniawan, N.A., Papantoniou, I., Pieuchot, L., Pires, T.H.V., Renner, L., Sageman-Furnas, A., Schröder-Turk, G.E., Sengupta, A., Sharma, V.R., Tagua, A., Tomba, C., Trepat, X., Waters, S.L., Yeo, E., Bidan, C.M. and Dunlop, J.W.C.: Curvature in Biological Systems: Its quantification, Emergence and Implications Across the Scales. Advanced Materials, 35, 2206110 (2023)

2022

Taïeb, H. M., Bertinetti, L., Robinson, T., Cipitria, A.: FUCCItrack: an all-in-one software for single cell tracking and cell cycle analysis. PLOS One 17(7):e0268297 (2022).

Young, S. A. E., Rummler, M., Taïeb, H. M., Garske, D. S., Ellinghaus, A., Duda, G. N., Willie, B. M., Cipitria. A.: In vivo microCT-based time-lapse morphometry reveals anatomical site-specific differences in bone (re)modeling serving as baseline parameters to detect early pathological events. Bone 161, 116432 (2022).

Perier-Metz, C., Cipitria, A., Hutmacher, D.W., Duda, G.N., Checa, S.: An in silico model predicts the impact of scaffold design in large bone defect regeneration. Acta Biomaterialia, 145, 329-341 (2022).

Bakhshandeh, S.; Werner, C.; Fratzl, P.; Cipitria, A.: Microenvironment-mediated cancer dormancy: Insights from metastability theory. Proceedings of the National Academy of Sciences

Lahr, C. A.; Landgraf, M.; Wagner, F.; Cipitria, A.; Moreno-Jiménez, I.; Bas, O.; Schmutz, B.; Meinert, C.; Dos Santos Cavalcanti, A.; Mashimoo, T.; Miyasaka, Y.; Holzapfel, B. M.; Shafiee, A.; McGovern, J.; Hutmacher, D. W.: A humanised rat model of osteosarcoma reveals ultrastructural differences between bone and mineralised tumour tissue. Bone 158, 116018 (2022)

2021

Schmuck, R.B.; Lippens, E.; Wulsten, D.; Garske, D.S.; Strönisch, A.; Pratschke, J.; Sauer, I.M.; Duda, G.N.; Bahra, M.; Cipitria, A.: Role of extracellular matrix structural components and tissue mechanics in the development of postoperative pancreatic fistula. Journal of Biomechanics 128, 110714 (2021)

Moreno-Jiménez, I.; Garske, D. S.; Lahr, C. A.; Hutmacher, D. W.; Cipitria, A.: Targeted 2D histology and ultrastructural bone analysis based on 3D microCT anatomical locations. MethodsX 8, 101480 (2021)

Taïeb, H. M.; Garske, D. S.; Contzen, J.; Gossen, M.; Bertinetti, L.; Robinson, T.; Cipitria, A.: Osmotic pressure modulates single cell cycle dynamics inducing reversible growth arrest and reactivation of human metastatic cells. Scientific Reports 11 (1), 13455 (2021)

Trujillo, S.; Seow, M.; Lueckgen, A.; Salmeron-Sanchez, M.; Cipitria, A.: Dynamic mechanical control of alginate-fibronectin hydrogels with dual crosslinking: covalent and ionic. Polymers 13 (3), 433 (2021)

Bakhshandeh, S.; Taïeb, H. M.; Schlüßler, R.; Kim, K.; Beck, T.; Taubenberger, A.; Guck, J.; Cipitria, A.: Optical quantification of intracellular mass density and cell mechanics in 3D mechanical confinement. Soft Matter 17 (4), S. 853 – 862 (2021)

2020

Moreno-Jiménez, I.; Cipitria, A.; Sánchez-Herrero, A.; Van Tol, A.; Roschger, A.; Lahr, C. A.; McGovern, J. A.; Hutmacher, D. W.; Fratzl, P.: Human and mouse bones physiologically integrate in a humanized mouse model while maintaining species-specific ultrastructure. Science Advances 6 (44), abb9265 (2020)

Lueckgen, A.; Garske, D.; Ellinghaus, A.; Mooney, D. J.; Duda, G. N.; Cipitria, A.: Dual alginate crosslinking for local patterning of biophysical and biochemical properties. Acta Biomaterialia 115, S. 185 – 196 (2020)

Ziouti, F.; Prates Soares, A.; Moreno-Jiménez, I.; Rack, A.; Bogen, B.; Cipitria, A.; Zaslansky, P.; Jundt, F.: An early myeloma bone disease model in skeletally mature mice as a platform for biomaterial characterization of the extracellular matrix. Journal of Oncology 2020, 3985315 (2020)

Garske, D.; Schmidt-Bleek, K.; Ellinghaus, A.; Dienelt, A.; Gu, L.; Mooney, D. J.; Duda, G.; Cipitria, A.: Alginate hydrogels for in vivo bone regeneration: the immune competence of the animal model matters. Tissue Engineering Part A 26 (15-16), S. 852 – 862 (2020)

Sparks, D. S.; Saifzadeh, S.; Savi, F. M.; Dlaska, C. E.; Berner, A.; Henkel, J.; Reichert, J. C.; Wullschleger, M.; Ren, J.; Cipitria, A.; McGovern J. A.; Steck R.; Wagels M.; Woodruff M. A.; Schuetz M. A.; Hutmacher D. W.: A preclinical large-animal model for the assessment of critical-size load-bearing bone defect reconstruction. Nature Protocols 15 (3), S. 877 – 924 (2020)

2019

Lueckgen, A.; Garske, D. S.; Ellinghaus, A.; Mooney, D. J.; Duda, G. N.; Cipitria, A.: Enzymatically-degradable alginate hydrogels promote cell spreading and in vivo tissue infiltration. Biomaterials 217, 119294 (2019)

2018

Lueckgen, A.; Garske, D. S.; Ellinghaus, A.; Desai, R. M.; Stafford, A. G.; Mooney, D. J.; Duda, G. N.; Cipitria, A.: Hydrolytically-degradable click-crosslinked alginate hydrogels. Biomaterials 181, S. 189 – 198 (2018)

2017

Cipitria, A.; Boettcher, K.; Schoenhals, S.; Garske, D. S.; Schmidt-Bleek, K.; Ellinghaus, A.; Dienelt, A.; Peters, A.; Mehta, M.; Madl, C. M.; Huebsch N.; Mooney D. J.; Duda G. N.: In-situ tissue regeneration through SDF-1α driven cell recruitment and stiffness-mediated bone regeneration in a critical-sized segmental femoral defect. Acta Biomaterialia 60, S. 50 – 63 (2017)

Cipitria, A.; Salmeron-Sanchez, M.: Mechanotransduction and Growth Factor Signalling to Engineer Cellular Microenvironments. Advanced Healthcare Materials 6 (15), 1700052 (2017)

Paris, M.; Götz, A.; Hettrich, I.; Bidan, C. M.; Dunlop, J. W. C.; Razi, H.; Zizak, I.; Hutmacher, D. W.; Fratzl, P.; Duda, G. N.; Wagermaier W.; Cipitria A.: Scaffold curvature-mediated novel biomineralization process originates a continuous soft tissue-to-bone interface. Acta Biomaterialia 60, S. 64 – 80 (2017)

2015

Cipitria, A.; Wagermaier, W.; Zaslansky, P.; Schell, H.; Reichert, J. C.; Fratzl, P.; Hutmacher, D. W.; Duda, G. N.: BMP delivery complements the guiding effect of scaffold architecture without altering bone microstructure in critical-sized long bone defects: a multiscale analysis. Acta Biomaterialia 23, S. 282 – 294 (2015)

2013

Cipitria, A. (shared first authorship); Reichert, J. C.; Epari, D. R.; Saifzadeh, S.; Berner, A.; Schell, H.; Mehta, M.; Schuetz, M. A.; Duda, G. N.; Hutmacher, D. W.: Polycaprolactone scaffold and reduced rhBMP-7 dose for the regeneration of critical-sized defects in sheep tibiae. Biomaterials 34 (38), S. 9960 – 9968 (2013)

2012

Reichert, J. C.; Cipitria, A. (shared first authorship); Epari, D. R.; Saifzadeh, S.; Krishnakanth, P.; Berner, A.; Woodruff, M. A.; Schell, H.; Mehta, M.; Schuetz, M. A.; Duda G. N.; Hutmacher D. W.: A Tissue Engineering Solution for Segmental Defect Regeneration in Load-Bearing Long Bones. Science Translational Medicine 4 (141), 141ra93 (2012)

Cipitria, A.; Lange, C.; Schell, H.; Wagermaier, W.; Reichert, J. C.; Hutmacher, D. W.; Fratzl, P.; Duda, G. N.: Porous scaffold architecture guides tissue formation. Journal of Bone and Mineral Research 27 (6), S. 1275 – 1288 (2012)

2011

Cipitria, A.; Skelton, A.; Dargaville, T. R.; Dalton, P. D.; Hutmacher, D. W.: Design, fabrication and characterization of PCL electrospun scaffolds-a review. Journal of Materials Chemistry 21 (26), S. 9419 – 9453 (2011)

Reichert, J. C.; Wullschleger, M. E.; Cipitria, A.; Lienau, J.; Cheng, T. K.; Schütz, M. A.; Duda, G. N.; Nöth, U.; Eulert, J.; Hutmacher, D. W.: Custom-made composite scaffolds for segmental defect repair in long bones. International Orthopaedics 35 (8), S. 1229 – 1236 (2011)

2010

Willie, B. M.; Petersen, A.; Schmidt-Bleek, K.; Cipitria, A.; Mehta, M.; Strube, P.; Lienau, J.; Wildemann, B.; Fratzl, P.; Duda, G.: Designing biomimetic scaffolds for bone regeneration: why aim for a copy of mature tissue properties if nature uses a different approach? Soft Matter 6 (20), S. 4976 – 4987 (2010)

2009

Cipitria, A.; Golosnoy, I.O.; Clyne, T.W.: A sintering model for plasma-sprayed zirconia TBCs. Part I: Free-standing coatings. Acta Materialia 57 (4), S. 980 – 992 (2009)

Cipitria, A.; Golosnoy, I.O.; Clyne, T.W.: A sintering model for plasma-sprayed zirconia thermal barrier coatings. Part II: Coatings bonded to a rigid substrate. Acta Materialia 57 (4), S. 993 – 1003 (2009)

Golosnoy, I. O.; Cipitria, A.; Clyne, T. W.: Heat Transfer Through Plasma-Sprayed Thermal Barrier Coatings in Gas Turbines: A Review of Recent Work. Journal of Thermal Spray Technology 18 (5), S. 809 – 821 (2009)

Paul, S.; Cipitria, A.; Tsipas, S.A.; Clyne, T.W.: Sintering characteristics of plasma sprayed zirconia coatings containing different stabilisers. Surface and Coatings Technology 203 (8), S. 1069 – 1074 (2009)

2007

Paul , S.; Cipitria, A.; Golosnoy, I.O.; Xie, L.; Dorfman, M.R.; Clyne, T.W.: Effects of Impurity Content on the Sintering Characteristics of Plasma-Sprayed Zirconia. Journal of Thermal Spray Technology 16 (5), S. 798 – 803 (2007)

Xie, L.; Dorfman, M.R.; Cipitria, A.; Paul, S.; Golosnoy, I.O.; Clyne, T.W.: Properties and Performance of High-Purity Thermal Barrier Coatings. Journal of Thermal Spray Technology 16 (5), S. 804 – 808 (2007)

Cipitria, A.; Golosnoy, I.O.; Clyne, T.W.: Sintering Kinetics of Plasma-Sprayed Zirconia TBCs. Journal of Thermal Spray Technology 16 (5), S. 809 – 815 (2007)